The skin is the body’s largest organ. It forms a barrier that
helps prevent harmful microorganisms and chemicals from entering the
body, and it also prevents the loss of body fluids. It protects the
vital structures inside the body from injury and from the potentially
damaging ultraviolet rays of the sun. The skin also helps regulate
body temperature, excretes some waste products, and is an important
sensory organ. Both delicate and resilient, the skin constantly
renews itself and has a remarkable ability to repair itself after
injury.
Layers of the
skin
The epidermis is composed of keratinized, stratified
squamous epithelium. It is made of four or five layers of epithelial
cells, depending on its location in the body. It does not have any
blood vessels within it . Skin that has four layers of cells is
referred to as “thin skin.” From deep to superficial, these
layers are the stratum basale, stratum spinosum, stratum granulosum,
and stratum corneum. Most of the skin can be classified as thin skin.
“Thick skin” is found only on the palms of the hands and the
soles of the feet. It has a fifth layer, called the stratum lucidum,
located between the stratum corneum and the stratum granulosum. The
epidermis is a continually renewing layer and gives rise to
derivative structures, such as pilosebaceous apparatuses, nails, and
sweat glands. The basal cells of the epidermis undergo proliferation
cycles that provide for the renewal of the outer epidermis. The
epidermis is a dynamic tissue in which cells are constantly in
unsynchronized motion, as differing individual cell populations pass
not only one another but also melanocytes and Langerhans cells as
they move toward the surface of the skin.
The dermis might be considered the “core” of the
integumentary system, as distinct from the epidermis (epi- = “upon”
or “over”) and hypodermis (hypo- = “below”). It contains
blood and lymph vessels, nerves, and other structures, such as hair
follicles and sweat glands. The dermis is made of two layers of
connective tissue that compose an interconnected mesh of elastin and
collagenous fibers, produced by fibroblasts. The dermis comprises
the bulk of the skin and provides its pliability, elasticity, and
tensile strength. It protects the body from mechanical injury, binds
water, aids in thermoregulation, and includes receptors of sensory
stimuli. The dermis interacts with the epidermis in maintaining the
properties of both tissues.
The hypodermis (also called the subcutaneous layer or
superficial fascia) is a layer directly below the dermis and is the
deepest section of the skin. It serves to connect the skin to the
underlying fascia (fibrous tissue) of the bones and muscles. It is
not strictly a part of the skin, although the border between the
hypodermis and dermis can be difficult to distinguish. The hypodermis
consists of well-vascularized, loose, areolar connective tissue and
adipose tissue, which functions as a mode of fat storage and provides
insulation and cushioning for the integument. The hypodermis refers
to the fat tissue below the dermis that insulates the body from cold
temperatures and provides shock absorption. Fat cells of the
hypodermis also store nutrients and energy. The hypodermis is the
thickest in the buttocks, palms of the hands, and soles of the feet.
As we age, the hypodermis begins to atrophy, contributing to the
thinning of aging skin.
This is a very basic overview of the physiology of the skin to
learn more refer to the American Academy of Dermatology.
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